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MedMASLab: A Unified Orchestration Framework for Benchmarking Multimodal Medical Multi-Agent Systems

arXiv cs.AI / 3/11/2026

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Key Points

  • MedMASLab is a unified orchestration framework designed to benchmark multimodal medical multi-agent systems (MAS), addressing fragmentation and lack of standardization in current medical MAS research.
  • The framework introduces a standardized multimodal agent communication protocol enabling integration of 11 heterogeneous MAS architectures across 24 medical modalities.
  • It features an automated clinical reasoning evaluator using zero-shot semantic evaluation with large vision-language models to assess diagnostic logic and visual grounding, overcoming limitations of lexical string-matching.
  • MedMASLab provides the most extensive benchmark to date, covering 11 organ systems and 473 diseases by standardizing data from 11 clinical benchmarks.
  • Evaluation reveals a domain-specific performance gap where MAS improve reasoning but exhibit fragility when transitioning between specialized medical sub-domains, establishing a new technical baseline for autonomous clinical systems.

Computer Science > Artificial Intelligence

arXiv:2603.09909 (cs)
[Submitted on 10 Mar 2026]

Title:MedMASLab: A Unified Orchestration Framework for Benchmarking Multimodal Medical Multi-Agent Systems

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Abstract:While Multi-Agent Systems (MAS) show potential for complex clinical decision support, the field remains hindered by architectural fragmentation and the lack of standardized multimodal integration. Current medical MAS research suffers from non-uniform data ingestion pipelines, inconsistent visual-reasoning evaluation, and a lack of cross-specialty benchmarking. To address these challenges, we present MedMASLab, a unified framework and benchmarking platform for multimodal medical multi-agent systems. MedMASLab introduces: (1) A standardized multimodal agent communication protocol that enables seamless integration of 11 heterogeneous MAS architectures across 24 medical modalities. (2) An automated clinical reasoning evaluator, a zero-shot semantic evaluation paradigm that overcomes the limitations of lexical string-matching by leveraging large vision-language models to verify diagnostic logic and visual grounding. (3) The most extensive benchmark to date, spanning 11 organ systems and 473 diseases, standardizing data from 11 clinical benchmarks. Our systematic evaluation reveals a critical domain-specific performance gap: while MAS improves reasoning depth, current architectures exhibit significant fragility when transitioning between specialized medical sub-domains. We provide a rigorous ablation of interaction mechanisms and cost-performance trade-offs, establishing a new technical baseline for future autonomous clinical systems. The source code and data is publicly available at: this https URL
Subjects: Artificial Intelligence (cs.AI)
Cite as: arXiv:2603.09909 [cs.AI]
  (or arXiv:2603.09909v1 [cs.AI] for this version)
  https://doi.org/10.48550/arXiv.2603.09909
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arXiv-issued DOI via DataCite

Submission history

From: Yunhang Qian [view email]
[v1] Tue, 10 Mar 2026 17:03:11 UTC (11,990 KB)
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