Multiple Domain Generalization Using Category Information Independent of Domain Differences

arXiv cs.CV / 4/9/2026

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Key Points

  • The paper addresses domain generalization, aiming to keep segmentation models accurate on unseen datasets whose imaging conditions differ from the training (source) domain.
  • It proposes a framework that decomposes features into category-relevant information that is independent of domain differences and information specific to the source domain.
  • Because domain-gap reduction is not fully solved by domain-invariant features alone, the approach further models residual domain differences using “quantum vectors” within a Stochastically Quantized Variational AutoEncoder (SQ-VAE).
  • Experiments on vascular segmentation and cell nucleus segmentation show that the combined method improves accuracy over conventional baselines.
  • Overall, the work focuses on robust medical-image segmentation under distribution shift by explicitly separating domain-independent semantics from domain-specific factors.

Abstract

Domain generalization is a technique aimed at enabling models to maintain high accuracy when applied to new environments or datasets (unseen domains) that differ from the datasets used in training. Generally, the accuracy of models trained on a specific dataset (source domain) often decreases significantly when evaluated on different datasets (target domain). This issue arises due to differences in domains caused by varying environmental conditions such as imaging equipment and staining methods. Therefore, we undertook two initiatives to perform segmentation that does not depend on domain differences. We propose a method that separates category information independent of domain differences from the information specific to the source domain. By using information independent of domain differences, our method enables learning the segmentation targets (e.g., blood vessels and cell nuclei). Although we extract independent information of domain differences, this cannot completely bridge the domain gap between training and test data. Therefore, we absorb the domain gap using the quantum vectors in Stochastically Quantized Variational AutoEncoder (SQ-VAE). In experiments, we evaluated our method on datasets for vascular segmentation and cell nucleus segmentation. Our methods improved the accuracy compared to conventional methods.