Implantable Adaptive Cells: A Novel Enhancement for Pre-Trained U-Nets in Medical Image Segmentation

arXiv cs.AI / 4/10/2026

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Key Points

  • The paper proposes Implantable Adaptive Cells (IAC): small, NAS-discovered modules that can be injected into the skip connections of an already trained U-Net to improve medical image segmentation.
  • IACs are identified using a Partially-Connected DARTS-based, gradient-driven Neural Architecture Search approach that targets refinement without requiring full retraining of the original model.
  • Experiments across four MRI/CT medical datasets (evaluating multiple U-Net configurations) show consistent performance gains, with segmentation accuracy improving by about 5 percentage points on average and up to ~11 percentage points in best cases.
  • The authors frame IAC as a cost-effective alternative to redesigning or retraining complex segmentation pipelines, and suggest the method may generalize to other architectures and domains beyond U-Net.
  • Overall, the work positions architecture “enhancement” modules as a practical way to leverage pre-trained networks while achieving measurable accuracy improvements in segmentation tasks.

Abstract

This paper introduces a novel approach to enhance the performance of pre-trained neural networks in medical image segmentation using gradient-based Neural Architecture Search (NAS) methods. We present the concept of Implantable Adaptive Cell (IAC), small modules identified through Partially-Connected DARTS based approach, designed to be injected into the skip connections of an existing and already trained U-shaped model. Unlike traditional NAS methods, our approach refines existing architectures without full retraining. Experiments on four medical datasets with MRI and CT images show consistent accuracy improvements on various U-Net configurations, with segmentation accuracy gain by approximately 5 percentage points across all validation datasets, with improvements reaching up to 11\%pt in the best-performing cases. The findings of this study not only offer a cost-effective alternative to the complete overhaul of complex models for performance upgrades but also indicate the potential applicability of our method to other architectures and problem domains.