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MAPLE: Elevating Medical Reasoning from Statistical Consensus to Process-Led Alignment

arXiv cs.LG / 3/11/2026

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Key Points

  • The paper presents a new training paradigm that integrates medical process reward models with Test-Time Reinforcement Learning (TTRL) to improve medical reasoning in large language models.
  • It replaces the conventional majority voting heuristic with a fine-grained, expert-aligned supervision approach using Med-RPM, focusing on medical correctness rather than frequency of reasoning paths.
  • This approach effectively distills search-based intelligence into the model's parametric memory, leading to better alignment between model outputs and clinical correctness.
  • Extensive evaluations across four benchmarks show significant performance improvements over existing TTRL and standalone process reward model methods.
  • The study highlights the importance of structured, step-wise medical reasoning rewards over stochastic heuristics for building reliable and scalable AI in healthcare.

Computer Science > Machine Learning

arXiv:2603.08987 (cs)
[Submitted on 9 Mar 2026]

Title:MAPLE: Elevating Medical Reasoning from Statistical Consensus to Process-Led Alignment

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Abstract:Recent advances in medical large language models have explored Test-Time Reinforcement Learning (TTRL) to enhance reasoning. However, standard TTRL often relies on majority voting (MV) as a heuristic supervision signal, which can be unreliable in complex medical scenarios where the most frequent reasoning path is not necessarily the clinically correct one. In this work, we propose a novel and unified training paradigm that integrates medical process reward models with TTRL to bridge the gap between test-time scaling (TTS) and parametric model optimization. Specifically, we advance the TTRL framework by replacing the conventional MV with a fine-grained, expert-aligned supervision paradigm using Med-RPM. This integration ensures that reinforcement learning is guided by medical correctness rather than mere consensus, effectively distilling search-based intelligence into the model's parametric memory. Extensive evaluations on four different benchmarks have demonstrated that our developed method consistently and significantly outperforms current TTRL and standalone PRM selection. Our findings establish that transitioning from stochastic heuristics to structured, step-wise rewards is essential for developing reliable and scalable medical AI systems
Subjects: Machine Learning (cs.LG)
Cite as: arXiv:2603.08987 [cs.LG]
  (or arXiv:2603.08987v1 [cs.LG] for this version)
  https://doi.org/10.48550/arXiv.2603.08987
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arXiv-issued DOI via DataCite

Submission history

From: Anqi Pu [view email]
[v1] Mon, 9 Mar 2026 22:22:57 UTC (203 KB)
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