Empowering Epidemic Response: The Role of Reinforcement Learning in Infectious Disease Control

arXiv cs.AI / 3/30/2026

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Key Points

  • The article reviews how reinforcement learning (RL) has been applied to infectious disease control to optimize intervention strategies for outbreak response.
  • It highlights RL’s suitability for dynamic, constraint-driven environments and notes a growing body of work focused on COVID-19 and other infectious diseases.
  • The review specifically covers RL-driven decision areas such as resource allocation, trade-offs between health outcomes and economic/social impacts, and combining multiple interventions.
  • It also discusses RL approaches for inter-regional coordinated control to manage spread across geographic areas.
  • The paper concludes by outlining open problems and promising directions for future RL research in public health intervention optimization.

Abstract

Reinforcement learning (RL), owing to its adaptability to various dynamic systems in many real-world scenarios and the capability of maximizing long-term outcomes under different constraints, has been used in infectious disease control to optimize the intervention strategies for controlling infectious disease spread and responding to outbreaks in recent years. The potential of RL for assisting public health sectors in preventing and controlling infectious diseases is gradually emerging and being explored by rapidly increasing publications relevant to COVID-19 and other infectious diseases. However, few surveys exclusively discuss this topic, that is, the development and application of RL approaches for optimizing strategies of non-pharmaceutical and pharmaceutical interventions of public health. Therefore, this paper aims to provide a concise review and discussion of the latest literature on how RL approaches have been used to assist in controlling the spread and outbreaks of infectious diseases, covering several critical topics addressing public health demands: resource allocation, balancing between lives and livelihoods, mixed policy of multiple interventions, and inter-regional coordinated control. Finally, we conclude the paper with a discussion of several potential directions for future research.